共 44 条
CTCF-dependent enhancer-blocking by alternative chromatin loop formation
被引:147
作者:

Hou, Chunhui
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA

Zhao, Hui
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA

Tanimoto, Keiji
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058577, Japan NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA

Dean, Ann
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA
机构:
[1] NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA
[2] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058577, Japan
来源:
基金:
美国国家卫生研究院;
关键词:
beta-globin genes;
insulator;
locus control region;
epigenetics;
transcription regulation;
D O I:
10.1073/pnas.0808506106
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The mechanism underlying enhancer-blocking by insulators is unclear. We explored the activity of human beta-globin HS5, the orthologue of the CTCF-dependent chicken HS4 insulator. An extra copy of HS5 placed between the beta-globin locus control region (LCR) and downstream genes on a transgene fulfills the classic predictions for an enhancer-blocker. Ectopic HS5 does not perturb the LCR but blocks gene activation by interfering with RNA pol II, activator and coactivator recruitment, and epigenetic modification at the downstream beta-globin gene. Underlying these effects, ectopic HS5 disrupts chromatin loop formation between beta-globin and the LCR, and instead forms a new loop with endogenous HS5 that topologically isolates the LCR. Both enhancer-blocking and insulator-loop formation depend on an intact CTCF site in ectopic HS5 and are sensitive to knock-down of the CTCF protein by siRNA. Thus, intrinsic looping activity of CTCF sites can nullify LCR function.
引用
收藏
页码:20398 / 20403
页数:6
相关论文
共 44 条
[31]
Cohesins functionally associate with CTCF on mammalian chromosome arms
[J].
Parelho, Vania
;
Hadjur, Suzana
;
Spivakov, Mikhail
;
Leleu, Marion
;
Sauer, Stephan
;
Gregson, Heather C.
;
Jarmuz, Adam
;
Canzonetta, Claudia
;
Webster, Zoe
;
Nesterova, Tatyana
;
Cobb, Bradley S.
;
Yokomori, Kyoko
;
Dillon, Niall
;
Aragon, Luis
;
Fisher, Amanda G.
;
Merkenschiager, Matthias
.
CELL,
2008, 132 (03)
:422-433

Parelho, Vania
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Hadjur, Suzana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Spivakov, Mikhail
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Leleu, Marion
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Sauer, Stephan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Gregson, Heather C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Sch Med, Dept Biol Chem, Irvine, CA 92697 USA Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Jarmuz, Adam
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Cell Cycle Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Canzonetta, Claudia
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Webster, Zoe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Nesterova, Tatyana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dev Epigenet Grp, MRC Clin Sci Ctr, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Cobb, Bradley S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Yokomori, Kyoko
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Sch Med, Dept Biol Chem, Irvine, CA 92697 USA Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Dillon, Niall
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Aragon, Luis
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Cell Cycle Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Fisher, Amanda G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England

Merkenschiager, Matthias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, London W12 0NN, England
[32]
The β-globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation
[J].
Sawado, T
;
Halow, J
;
Bender, MA
;
Groudine, M
.
GENES & DEVELOPMENT,
2003, 17 (08)
:1009-1018

Sawado, T
论文数: 0 引用数: 0
h-index: 0
机构: Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

Halow, J
论文数: 0 引用数: 0
h-index: 0
机构: Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

Bender, MA
论文数: 0 引用数: 0
h-index: 0
机构: Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

Groudine, M
论文数: 0 引用数: 0
h-index: 0
机构: Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA
[33]
A positive role for NLI/Ldb1 in long-range β-globin locus control region function
[J].
Song, Sang-Hyun
;
Hou, Chunhui
;
Dean, Ann
.
MOLECULAR CELL,
2007, 28 (05)
:810-822

Song, Sang-Hyun
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA

Hou, Chunhui
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA

Dean, Ann
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA
[34]
CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus
[J].
Splinter, Erik
;
Heath, Helen
;
Kooren, Jurgen
;
Palstra, Robert-Jan
;
Klous, Petra
;
Grosveld, Frank
;
Galjart, Niels
;
de Laat, Wouter
.
GENES & DEVELOPMENT,
2006, 20 (17)
:2349-2354

Splinter, Erik
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Heath, Helen
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Kooren, Jurgen
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Palstra, Robert-Jan
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Klous, Petra
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Grosveld, Frank
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Galjart, Niels
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

de Laat, Wouter
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands
[35]
Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators
[J].
Stedman, William
;
Kang, Hyojeung
;
Lin, Shu
;
Kissil, Joseph L.
;
Bartolomei, Marisa S.
;
Lieberman, Paul M.
.
EMBO JOURNAL,
2008, 27 (04)
:654-666

Stedman, William
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA

Kang, Hyojeung
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA

Lin, Shu
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA

Kissil, Joseph L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA

Bartolomei, Marisa S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA

Lieberman, Paul M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA Univ Penn, Wistar Inst, Gene Regulat Program, Philadelphia, PA 19104 USA
[36]
Human β-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells
[J].
Tanimoto, K
;
Sugiura, A
;
Omori, A
;
Felsenfeld, G
;
Engel, JD
;
Fukamizu, A
.
MOLECULAR AND CELLULAR BIOLOGY,
2003, 23 (24)
:8946-8952

Tanimoto, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Inst Appl Biochem, Tsukuba, Ibaraki 3058577, Japan

Sugiura, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Inst Appl Biochem, Tsukuba, Ibaraki 3058577, Japan

Omori, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Inst Appl Biochem, Tsukuba, Ibaraki 3058577, Japan

Felsenfeld, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Inst Appl Biochem, Tsukuba, Ibaraki 3058577, Japan

Engel, JD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Inst Appl Biochem, Tsukuba, Ibaraki 3058577, Japan

Fukamizu, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Inst Appl Biochem, Tsukuba, Ibaraki 3058577, Japan
[37]
Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice
[J].
Tanimoto, K
;
Liu, QH
;
Bungert, J
;
Engel, JD
.
NATURE,
1999, 398 (6725)
:344-348

Tanimoto, K
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

Liu, QH
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

Bungert, J
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

Engel, JD
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA
[38]
Looping and interaction between hypersensitive sites in the active β-globin locus
[J].
Tolhuis, B
;
Palstra, RJ
;
Splinter, E
;
Grosveld, F
;
de Laat, W
.
MOLECULAR CELL,
2002, 10 (06)
:1453-1465

Tolhuis, B
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Palstra, RJ
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Splinter, E
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

Grosveld, F
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

de Laat, W
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Univ, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands
[39]
Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1
[J].
Vakoc, CR
;
Letting, DL
;
Gheldof, N
;
Sawado, T
;
Bender, MA
;
Groudine, M
;
Weiss, MJ
;
Dekker, J
;
Blobel, GA
.
MOLECULAR CELL,
2005, 17 (03)
:453-462

Vakoc, CR
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

Letting, DL
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

Gheldof, N
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

Sawado, T
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

Bender, MA
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

Groudine, M
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

Weiss, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

论文数: 引用数:
h-index:
机构:

Blobel, GA
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA
[40]
HS5 of the human β-globin locus control region:: a developmental stage-specific border in erythroid cells
[J].
Wai, AWK
;
Gillemans, N
;
Raguz-Bolognesi, S
;
Pruzina, S
;
Zafarana, G
;
Meijer, D
;
Philipsen, S
;
Grosveld, F
.
EMBO JOURNAL,
2003, 22 (17)
:4489-4500

Wai, AWK
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus MC, Dept Cell Biol, NL-3000 DR Rotterdam, Netherlands

Gillemans, N
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus MC, Dept Cell Biol, NL-3000 DR Rotterdam, Netherlands

Raguz-Bolognesi, S
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus MC, Dept Cell Biol, NL-3000 DR Rotterdam, Netherlands

Pruzina, S
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus MC, Dept Cell Biol, NL-3000 DR Rotterdam, Netherlands

Zafarana, G
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus MC, Dept Cell Biol, NL-3000 DR Rotterdam, Netherlands

Meijer, D
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus MC, Dept Cell Biol, NL-3000 DR Rotterdam, Netherlands

Philipsen, S
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus MC, Dept Cell Biol, NL-3000 DR Rotterdam, Netherlands

Grosveld, F
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus MC, Dept Cell Biol, NL-3000 DR Rotterdam, Netherlands