Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis

被引：65

作者：

Jung, JU

Choi, JK

Ensser, A

Biesinger, B

机构：

[1] Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA

[2] Univ Erlangen Nurnberg, Inst Klin & Mol Virol, D-91054 Erlangen, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 03期

关键词：

Herpesvirus saimiri; transformation; oncogene; virus-encoded cellular homologues; animal model;

D O I：

10.1006/scbi.1998.0115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Herpesvirus saimiri (HVS) causes T-lymphoproliferative disorders in several New World and Old World primate species and in certain rabbits. In vitro infection leads to permanent growth of primary T cells of primate and human origins. The transformation-relevant proteins of HVS interact with cellular proto-oncoproteins which results in cell growth transformation. In addition, virus-encoded cellular homologues may contribute to transformation or persistence of HVS by altering cellular signal transduction and deregulating cell growth control. Because of the presence of a permissive cell culture system and in vitro and in vivo transformation assays, HVS provides a unique opportunity to investigate the mechanisms of cancer induction by oncogenic herpesviruses.

引用

页码：231 / 239

页数：9

共 98 条

[1] HERPESVIRUS SAIMIRI-INDUCED LYMPHOBLASTOID RABBIT-CELL LINE - GROWTH-CHARACTERISTICS, VIRUS PERSISTENCE, AND ONCOGENIC PROPERTIES [J].

ABLASHI, DV ;

SCHIRM, S ;

FLECKENSTEIN, B ;

FAGGIONI, A ;

DAHLBERG, J ;

RABIN, H ;

LOEB, W ;

ARMSTRONG, G ;

PENG, JW ;

AULAHK, G ;

TORRISI, MR .

JOURNAL OF VIROLOGY, 1985, 55 (03) :623-633

[2] LYMPHOKINES PRODUCED BY HERPESVIRUS-TRANSFORMED MARMOSET MONKEY LYMPHOID-CELL LINES .1. CHARACTERIZATION OF A CONSTITUTIVELY PRODUCED INTERFERON [J].

ADOLF, GR .

VIROLOGY, 1984, 137 (01) :195-200

[3]

AHUJA SK, 1993, J BIOL CHEM, V268, P20691

[4] In vitro immortalization of Old World monkey T lymphocytes with Herpesvirus Saimiri: Its susceptibility to infection with simian immunodeficiency viruses [J].

Akari, H ;

Mori, K ;

Terao, K ;

Otani, I ;

Fukasawa, M ;

Mukai, R ;

Yoshikawa, Y .

VIROLOGY, 1996, 218 (02) :382-388

[5] PRIMARY STRUCTURE OF THE HERPESVIRUS SAIMIRI GENOME [J].

ALBRECHT, JC ;

NICHOLAS, J ;

BILLER, D ;

CAMERON, KR ;

BIESINGER, B ;

NEWMAN, C ;

WITTMANN, S ;

CRAXTON, MA ;

COLEMAN, H ;

FLECKENSTEIN, B ;

HONESS, RW .

JOURNAL OF VIROLOGY, 1992, 66 (08) :5047-5058

[6] A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 Nef alleles in lymphocyte activation [J].

Alexander, L ;

Du, ZJ ;

Rosenzweig, M ;

Jung, JU ;

Desrosiers, RC .

JOURNAL OF VIROLOGY, 1997, 71 (08) :6094-6099

[7] PHENOTYPIC AND FUNCTIONAL CONSEQUENCES OF HERPESVIRUS SAIMIRI INFECTION OF HUMAN CD8+ CYTOTOXIC T-LYMPHOCYTES [J].

BEREND, KR ;

JUNG, JU ;

BOYLE, TJ ;

DIMAIO, JM ;

MUNGAL, SA ;

DESROSIERS, RC ;

LYERLY, HK .

JOURNAL OF VIROLOGY, 1993, 67 (10) :6317-6321

[8]

BERTRAM KA, 1983, J NATL CANCER I, V70, P147

[9] THE DIVERGENCE BETWEEN 2 ONCOGENIC HERPESVIRUS-SAIMIRI STRAINS IN A GENOMIC REGION RELATED TO THE TRANSFORMING PHENOTYPE [J].

BIESINGER, B ;

TRIMBLE, JJ ;

DESROSIERS, RC ;

FLECKENSTEIN, B .

VIROLOGY, 1990, 176 (02) :505-514

[10] THE PRODUCT OF THE HERPESVIRUS-SAIMIRI OPEN READING FRAME-1 (TIP) INTERACTS WITH T-CELL-SPECIFIC KINASE P56(LCK) IN TRANSFORMED-CELLS [J].

BIESINGER, B ;

TSYGANKOV, AY ;

FICKENSCHER, H ;

EMMRICH, F ;

FLECKENSTEIN, B ;

BOLEN, JB ;

BROKER, BM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (09) :4729-4734

← 1 2 3 4 5 6 7 8 9 10 →