Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis

被引：65

作者：

Jung, JU

Choi, JK

Ensser, A

Biesinger, B

机构：

[1] Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA

[2] Univ Erlangen Nurnberg, Inst Klin & Mol Virol, D-91054 Erlangen, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 03期

关键词：

Herpesvirus saimiri; transformation; oncogene; virus-encoded cellular homologues; animal model;

D O I：

10.1006/scbi.1998.0115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Herpesvirus saimiri (HVS) causes T-lymphoproliferative disorders in several New World and Old World primate species and in certain rabbits. In vitro infection leads to permanent growth of primary T cells of primate and human origins. The transformation-relevant proteins of HVS interact with cellular proto-oncoproteins which results in cell growth transformation. In addition, virus-encoded cellular homologues may contribute to transformation or persistence of HVS by altering cellular signal transduction and deregulating cell growth control. Because of the presence of a permissive cell culture system and in vitro and in vivo transformation assays, HVS provides a unique opportunity to investigate the mechanisms of cancer induction by oncogenic herpesviruses.

引用

页码：231 / 239

页数：9

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