How telomerase reaches its end: Mechanism of telomerase regulation by the telomeric complex

被引：122

作者：

Bianchi, Alessandro ^{[1
,2
]}

Shore, David ^{[1
,2
]}

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland

[2] Univ Geneva, NCCR Frontiers Genet Program, CH-1211 Geneva, Switzerland

来源：

MOLECULAR CELL | 2008年 / 31卷 / 02期

关键词：

D O I：

10.1016/j.molcel.2008.06.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at individual chromosome ends by the telomeric protein/DNA complex in a manner dependent on telomere repeat-array length. A dynamic interplay between telomerase-inhibiting factors bound at duplex DNA repeats and telomerasepromoting ones bound at single-stranded terminal DNA overhangs appears to modulate telomerase activity and to be directly related to the transient deprotection of telomeres. We discuss recent advances on the mechanism of telomerase regulation at chromosome ends in both yeast and mammalian systems.

引用

页码：153 / 165

页数：13

共 124 条

[1] A topological mechanism for TRF2-enhanced strand invasion
Amiard, Simon
Doudeau, Michel
Pinte, Sebastien
Poulet, Anais
Lenain, Christelle
Faivre-Moskalenko, Cendrine
Angelov, Dimitar
Hug, Nele
Vindigni, Alessandro
Bouvet, Philippe
Paoletti, Jacques
Gilson, Eric
Giraud-Panis, Marie-Josephe
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (02) : 147 - 154
[2] Targeting assay to study the cis functions of human telomeric proteins:: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2
Ancelin, K
Brunori, M
Bauwens, S
Koering, CE
Brun, C
Ricoul, M
Pommier, JP
Sabatier, L
Gilson, E
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (10) : 3474 - 3487
[3] Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break
Anderson, Carol M.
Korkin, Dmitry
Smith, Dana L.
Makovets, Svetlana
Seidel, Jeffrey J.
Sali, Andrej
Blackburn, Elizabeth H.
[J]. GENES & DEVELOPMENT, 2008, 22 (07) : 854 - 859
[4] Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination
不详
[J]. MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (02) : 597 - 608
[5] N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo
Armbruster, BN
Banik, SSR
Guo, CH
Smith, AC
Counter, CM
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (22) : 7775 - 7786
[6] Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast
Arneric, Milica
Lingner, Joachim
[J]. EMBO REPORTS, 2007, 8 (11) : 1080 - 1085
[7] The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle
Aylon, Y
Liefshitz, B
Kupiec, M
[J]. EMBO JOURNAL, 2004, 23 (24) : 4868 - 4875
[8] Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends
Azzalin, Claus M.
Reichenbach, Patrick
Khoriauli, Lela
Giulotto, Elena
Lingner, Joachim
[J]. SCIENCE, 2007, 318 (5851) : 798 - 801
[9] Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes
Bhaskara, Venugopal
Dupre, Aude
Lengsfeld, Bettina
Hopkins, Ben B.
Chan, Angela
Lee, Ji-Hoon
Zhang, Xiaoming
Gautier, Jean
Zakian, Virginia
Paull, Tanya T.
[J]. MOLECULAR CELL, 2007, 25 (05) : 647 - 661
[10] Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1
Bianchi, A
Negrini, S
Shore, D
[J]. MOLECULAR CELL, 2004, 16 (01) : 139 - 146

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