The role of glycogen synthase in the development of hyperglycemia in type 2 diabetes - 'To store or not to store glucose, that's the question'

被引：28

作者：

Beck-Nielsen, Henning ^{[1
]}

机构：

[1] Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense C, Denmark

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2012年 / 28卷 / 08期

关键词：

metabolic syndrome; insulin sensitivity and resistance; glycogen synthase; lipotoxicity; hyperglycemia; NUCLEAR-MAGNETIC-RESONANCE; SKELETAL-MUSCLE; INSULIN ACTION; OBESE-PATIENTS; METABOLISM; ACTIVATION; PHOSPHORYLATION; TRANSPORT; GLUT4; MICE;

D O I：

10.1002/dmrr.2337

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

This review deals with the role of glycogen storage in skeletal muscle for the development of insulin resistance and type 2 diabetes. Specifically, the role of the enzyme glycogen synthase, which seems to be locked in its hyperphosphorylated and inactivated state, is discussed. This defect seems to be secondary to ectopic lipid disposition in the muscle cells. These molecular defects are discussed in the context of the overall pathophysiology of hyperglycemia in type 2 diabetic subjects. Copyright (C) 2012 John Wiley & Sons, Ltd.

引用

页码：635 / 644

页数：10

共 48 条

[1]

Control of glycogen synthesis is shared between glucose transport and glycogen synthase in skeletal muscle fibers [J].