Innate and adaptive immune responses to viral infection and vaccination

被引：122

作者：

Aoshi, Taiki ^{[1
,2
]}

Koyama, Shohei ^{[3
]}

Kobiyama, Kouji ^{[1
,2
]}

Akira, Shizuo ^{[4
]}

Ishii, Ken J. ^{[1
,2
]}

机构：

[1] Natl Inst Biomed Innovat, Lab Adjuvant Innovat, Osaka, Japan

[2] Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Vaccine Sci, Osaka, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Resp Med, Sendai, Miyagi 980, Japan

[4] Osaka Univ, WPI Immunol Frontier Res Ctr, Host Def Lab, Osaka, Japan

来源：

CURRENT OPINION IN VIROLOGY | 2011年 / 1卷 / 04期

关键词：

TOLL-LIKE RECEPTORS; PATTERN-RECOGNITION RECEPTORS; INFLUENZA-A-VIRUS; PLASMACYTOID DENDRITIC CELLS; YELLOW-FEVER VACCINE; DOUBLE-STRANDED-RNA; RIG-I; FRANCISELLA-TULARENSIS; ANTIVIRAL RESPONSES; AIM2; INFLAMMASOME;

D O I：

10.1016/j.coviro.2011.07.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent accumulating evidence suggests that the human immune system possesses a variety of innate receptors that recognize, distinguish, and respond to viral infections and to vaccination. These include Toll-like receptors, C-type lectin receptors, RIG-I-like receptors, Nod-like receptors and possibly AIM2-like receptors. However, the precise mechanisms by which these receptors exert their critical roles in the induction of virus-specific adaptive immune responses have not been fully elucidated. In this review, we discuss recent advances in our understanding of the innate immune recognition of viruses and the differential connection to the adaptive immune responses induced by infection or vaccination, with a particular focus on the influenza virus.

引用

页码：226 / 232

页数：7

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