Aerobic Synthesis of Substituted Quinoline from Aldehyde and Aniline: Copper-Catalyzed Intermolecular C-H Active and C-C Formative Cyclization

被引：110

作者：

Yan, Rulong ^{[1
]}

Liu, Xingxing ^{[1
]}

Pan, Congming ^{[2
]}

Zhou, Xiaoqiang ^{[1
]}

Li, Xiaoni ^{[1
]}

Kang, Xing ^{[1
]}

Huang, Guosheng ^{[1
]}

机构：

[1] Lanzhou Univ, Dept Chem, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

[2] Jinchuan Grp Co Ltd, Jinchang City, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 18期

基金：

中国国家自然科学基金;

关键词：

POLYSUBSTITUTED PYRROLES; EFFICIENT SYNTHESIS; BOND ACTIVATION; PALLADIUM; MILD; FUNCTIONALIZATION; ANNULATION; AMIDATION; OXIDATION; ALKALOIDS;

D O I：

10.1021/ol402312h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the direct synthesis of substituted quinolines from anilines and aldehydes through C-H functionalization, C-C/C-N bond formation, and C-C bond cleavage has been developed. The method is simple and practical and employs air as an oxidant.

引用

页码：4876 / 4879

页数：4

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