Rhodium-Catalyzed C-C Bond Formation via Heteroatom-Directed C-H Bond Activation

Several researchers conducted studies to demonstrate rhodium-catalyzed C-C bond formation through heteroatom-directed C-H bond activation. A key issue in the development of C-H bond functionalization method involved the selective reactivity of a targeted C-H bond over the others present in a molecule. Lim and Kang were two researchers who conducted significant studies in the field, employing pyridine groups to direct functionalization. The immune functionality was also widely used and developed in the area of C-H bond functionlization by rhodium (Rh). The Rh-catalyzed alkylation of N-benzyl aryl ketimines was found to have significant scope than the Rh-catalyzed alkylation of aryl ketones in such reactions. The ketimines reacted cleanly with a wider range of alkenes than that was potentially employed in the Rh-mediated aryl ketone alkylation.