Palladium-catalyzed alkylation-alkenylation reactions: Rapid access to tricyclic mescaline analogues

被引：14

作者：

Alberico, Dino ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada

来源：

SYNLETT | 2006年 / 18期

关键词：

palladium; annulations; Heck reaction; mescaline; microwave irradiation;

D O I：

10.1055/s-2006-941583

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A norbomene-mediated palladium-catalyzed sequence is described in which two alkyl-aryl bonds and one alkenyl-aryl bond are formed in one pot. A variety of symmetrical and unsymmetrical tricyclic heterocycles were synthesized in good yields from a Heck acceptor and an aryl iodide containing two tethered alkyl bromides. This methodology was applied to the synthesis of a tricyclic mescaline analogue.

引用

页码：2969 / 2972

页数：4

共 43 条

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