Biomimetic synthesis of (±)-aculeatin D

被引：49

作者：

Baldwin, JE

Adlington, RM

Sham, VWW

Marquez, R

Bulger, PG

机构：

[1] Scripps Res Inst, La Jolla, CA 92037 USA

[2] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[3] Univ Dundee, Sch Life Sci, Dundee DD1 4HN, Scotland

来源：

TETRAHEDRON | 2005年 / 61卷 / 09期

关键词：

biomimetic synthesis; aculeatin D; oxidative cyclisation; hypervalent iodine reagents;

D O I：

10.1016/j.tet.2005.01.021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical, efficient and diastereoselective synthesis of the cytotoxic and antiprotozoal compound aculeatin D (1) is described, employing a biomimetic oxidative cyclisation cascade reaction to generate the tricyclic system of the natural product. The synthesis proceeds in ten steps from commercially available 1-tetradecanol. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2353 / 2363

页数：11

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