Genome Evolution Following Host Jumps in the Irish Potato Famine Pathogen Lineage

被引：299

作者：

Raffaele, Sylvain ^{[1
]}

Farrer, Rhys A. ^{[1
]}

Cano, Liliana M. ^{[1
]}

Studholme, David J. ^{[1
]}

MacLean, Daniel ^{[1
]}

Thines, Marco ^{[1
,2
,3
]}

Jiang, Rays H. Y. ^{[4
]}

Zody, Michael C. ^{[4
]}

Kunjeti, Sridhara G. ^{[5
]}

Donofrio, Nicole M. ^{[5
]}

Meyers, Blake C. ^{[5
]}

Nusbaum, Chad ^{[4
]}

Kamoun, Sophien ^{[1
]}

机构：

[1] Sainsbury Lab, Norwich NR4 7UH, Norfolk, England

[2] Biodivers & Climate Res Ctr BiK F, D-60325 Frankfurt, Germany

[3] Goethe Univ Frankfurt, Inst Ecol Evolut & Divers, Dept Biol Sci, D-60323 Frankfurt, Germany

[4] Massachusetts Inst Technol & Harvard, Broad Inst, Cambridge, MA 02141 USA

[5] Univ Delaware, Newark, DE 19716 USA

来源：

SCIENCE | 2010年 / 330卷 / 6010期

关键词：

PHYTOPHTHORA-INFESTANS; HISTONE METHYLATION; RXLR EFFECTORS; SEQUENCES; DISEASE;

D O I：

10.1126/science.1193070

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many plant pathogens, including those in the lineage of the Irish potato famine organism Phytophthora infestans, evolve by host jumps followed by specialization. However, how host jumps affect genome evolution remains largely unknown. To determine the patterns of sequence variation in the P. infestans lineage, we resequenced six genomes of four sister species. This revealed uneven evolutionary rates across genomes with genes in repeat-rich regions showing higher rates of structural polymorphisms and positive selection. These loci are enriched in genes induced in planta, implicating host adaptation in genome evolution. Unexpectedly, genes involved in epigenetic processes formed another class of rapidly evolving residents of the gene-sparse regions. These results demonstrate that dynamic repeat-rich genome compartments underpin accelerated gene evolution following host jumps in this pathogen lineage.

引用

页码：1540 / 1543

页数：4

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