Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide

被引：52

作者：

Kostakis, Ioannis K.

Elomri, Abdelhakim

Seguin, Elisabeth

Iannelli, Mauro

Besson, Thierry

机构：

[1] Univ Rouen, CNRS, UMR 6014, Grp Chim Pharmaceut,UFR Med Pharm, F-76183 Rouen, France

[2] Milestone Srl, I-24010 Sorisole, BG, Italy

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 38期

关键词：

microwave-assisted chemistry; quinazolin-4-ones; benzoxazin-4-ones; formamide;

D O I：

10.1016/j.tetlet.2007.07.114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H) -ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6609 / 6613

页数：5

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