Yb(OTf)3-catalyzed one-pot synthesis of quinazolin-4(3H)-ones from anthranilic acid, amines and ortho esters (or formic acid) in solvent-free conditions

被引：121

作者：

Wang, LM

Xia, JJ

Qin, F

Qian, CT

Sun, J

机构：

[1] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Organomet Chem Lab, Shanghai 200032, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2003年 / 08期

关键词：

quinazolin-4(3H)-ones; ytterbium triflate; one-pot reaction; anthranilic acid; amine;

D O I：

10.1055/s-2003-39397

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, ortho esters (or formic acid) and amines using Yb(OTf)(3) in one-pot under solvent-free conditions is described. Compared with the classical reaction conditions, this new synthetic method has the advantage of excellent yields (75-99%), shorter reaction time (few minutes) and reusability of the catalyst.

引用

收藏

页码：1241 / 1247

页数：7

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