Opinion - Targeting polo-like kinase 1 for cancer therapy

被引：708

作者：

Strebhardt, K

Ullrich, A

机构：

[1] Goethe Univ Frankfurt, Dept Obstet & Gynecol, Sch Med, D-60590 Frankfurt, Germany

[2] Inst Mol & Cell Biol, Singapore Oncogenome Lab, Ctr Mol Med, Singapore 138673, Singapore

[3] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 04期

关键词：

D O I：

10.1038/nrc1841

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in cancer, indicating its involvement in carcinogenesis and its potential as a therapeutic target. The use of different PLK1 inhibitors has increased our knowledge of mitotic regulation and allowed us to assess their ability to suppress tumour growth in vivo. We address the structural features of the kinase domain and the unique polo-box domain of PLK1 that are most suited for drug development and discuss our current understanding of the therapeutic potential of PLK1.

引用

收藏

页码：321 / 330

页数：10

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