DNA Helicases required for homologous recombination and repair of damaged replication forks

被引：140

作者：

Wu, Leonard ^{[1
]}

Hickson, Ian D. ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Canc Res UK, Oxford OX3 9DS, England

来源：

ANNUAL REVIEW OF GENETICS | 2006年 / 40卷

关键词：

holliday junction dissolution; D-loops; synthesis-dependent strand annealing; RecQ family; double-strand break repair;

D O I：

10.1146/annurev.genet.40.110405.090636

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA helicases are found in all kingdoms of life and function in all DNA metabolic processes where the two strands of duplex DNA require to be separated. Here, we review recent developments in our understanding of the roles that helicases play in the intimately linked processes of replication fork repair and homologous recombination, and highlight how the cell has evolved many distinct, and sometimes antagonistic, uses for these enzymes.

引用

页码：279 / 306

页数：28

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