Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats

被引:38
作者
Carlezon, WA
Rohan, ML
Mague, SD
Meloni, EG
Parsegian, A
Cayetano, K
Tomasiewicz, HC
Rouse, ED
Cohen, BM
Renshaw, PF
机构
[1] McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
[2] Harvard Univ, Sch Med, Belmont, MD USA
关键词
depression; fear; memory; model; rat; bipolar; MRI; human;
D O I
10.1016/j.biopsych.2004.12.011
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Background: Evidence suggests that a novel type of magnetic resonance imaging (MRI) scan called echo planar magnetic resonance spectroscopic imaging (EP-MRSI) has mood-elevating actions in humans during the depressive phases of bipolar disorder. We examined whether a low-energy component of EP-MRSI (low-field magnetic stimulation [LFMS]) has antidepressant-like, locomotor-stimulating, or amnestic effects in rats. Methods: We examined the effects of LFMS on immobility in the forced swim test (FST) and activity within an open field in separate groups of rats. After exposure to forced swimming, rats received LFMS (three 20-min sessions at 1.5 G/cm and .75 V/m) before behavioral testing. We also examined the effects of LFMS on fear conditioning (FC), a learning paradigm that also involves exposure to stressful conditions. Results: Low-field magnetic stimulation reduced immobility in the FST an antidepressant-like effect qualitatively similar to that of standard antidepressants. Low-field magnetic stimulation did not alter locomotor activity or FC. Conclusions: Low-field magnetic stimulation has antidepressant-like effects in rats that seem. unrelated to locomotor-activating or amnestic effects. These findings raise the possibility that electromagnetic fields can affect the brain biology and might have physiologic consequences that offer novel approaches to therapy for psychiatric disorders. These same consequences might render MRI-based scans more invasive than previously appreciated.
引用
收藏
页码:571 / 576
页数:6
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