Solid support synthesis of 14-membered macrocycles containing the thioether bridge via SNAr methodology

被引：23

作者：

Kiselyov, AS ^{[1
]}

Eisenberg, S ^{[1
]}

Luo, Y ^{[1
]}

机构：

[1] Amgen Inc, Small Mol Drug Discovery, Thousand Oaks, CA 91320 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(98)00598-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient assembly of 14-membered macrocycles utilizing the SNAr of fluorine in 3-fluoro-4-nitrobenzoic acid with the SH of cysteine on solid support is reported. The flexibility of this synthesis, as well as the excellent;purity (>90%) of the final products, are the distinctive characteristics of the resulting library. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：10635 / 10640

页数：6

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