Reissert Indole Synthesis Using Continuous-Flow Hydrogenation

被引：24

作者：

Colombo, Eloic ^{[1
]}

Ratel, Philippe ^{[1
]}

Mounier, Laurent ^{[1
]}

Guillier, Fabrice ^{[1
]}

机构：

[1] Labs Fournier SA, Chem Design & Synth Unit, F-21310 Daix, France

来源：

JOURNAL OF FLOW CHEMISTRY | 2011年 / 1卷 / 02期

关键词：

heterogeneous catalysis; reduction; Reissert indole synthesis; heterocycle; design of experiments; MICROREACTOR TECHNOLOGY; HIGH-PRESSURE; REACTOR; CONSTRUCTION; CYCLIZATION; CHEMISTRY; DESIGN;

D O I：

10.1556/jfchem.2011.00009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of substituted indole-2-carboxylic acid ethyl esters and aza-indole analogs have been prepared using continuous-flow hydrogenation. The identification of some key parameters using a design of experiments (DoE)-based approach allowed efficient optimization of each synthesis. The scale-up study for the multigram preparation of one model indole substrate showed the importance of working at steady state with the H-Cube apparatus. A new useful method for the easy preparation of substituted indoles in various quantities is presented.

引用

页码：68 / U62

页数：45

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