Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China

被引：43

作者：

Sun, Zhaogang ^{[1
]}

Chao, Yanjie ^{[2
]}

Zhang, Xuxia ^{[1
]}

Zhang, Jianyuan ^{[1
]}

Li, Yan ^{[1
]}

Qiu, Yunqing ^{[1
]}

Liu, Yi ^{[1
]}

Nie, Lihui ^{[1
]}

Guo, Aizhen ^{[2
]}

Li, Chuanyou ^{[1
]}

机构：

[1] Beijing TB & Thorac Tumor Res Inst, Dept Bacteriol & Immunol, Beijing 101149, Peoples R China

[2] Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 12期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1128/JCM.00822-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Thirteen extensively drug-resistant tuberculosis isolates which were highly resistant to a broad spectrum of antituberculosis drugs were identified from 1,926 clinical isolates in China. They had highly diverse mycobacterial interspersed repetitive-unit-variable-number tandem-repeat patterns. Most, but not all, of the drug target genes had mutations contributing to resistance to the corresponding drug.

引用

页码：4075 / 4077

页数：3

共 13 条

[1]

[Anonymous], 2006, Wkly Epidemiol Rec, V81, P408

[2]

Cohen J, 2006, SCIENCE, V313, P1554

[3] Genetic diversity in the Mycobacterium tuberculosis complex based on variable numbers of tandem DNA repeats [J].

Frothingham, R ;

Meeker-O'Connell, WA .

MICROBIOLOGY-UK, 1998, 144 :1189-1196

[4] Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa [J].

Gandhi, Neel R. ;

Moll, Anthony ;

Sturm, A. Willem ;

Pawinski, Robert ;

Govender, Thiloshini ;

Lalloo, Umesh ;

Zeller, Kimberly ;

Andrews, Jason ;

Friedland, Gerald .

LANCET, 2006, 368 (9547) :1575-1580

[5]

GANDHI NR, 2006, 16 INT AIDS C TOR CA, P13

[6] Utility of mycobacterial interspersed repetitive unit typing for differentiating Mycobacterium tuberculosis isolates in Wuhan, China [J].

Han, Hui ;

Wang, Fang ;

Xiao, Yong ;

Ren, Yi ;

Chao, Yanjie ;

Guo, Aizhen ;

Ye, Lingxiang .

JOURNAL OF MEDICAL MICROBIOLOGY, 2007, 56 (09) :1219-1223

[7] Evaluation of the epidemiologic utility of secondary typing methods for differentiation of Mycobacterium tuberculosis isolates [J].

Kwara, A ;

Schiro, R ;

Cowan, LS ;

Hyslop, NE ;

Wiser, MF ;

Harrison, SR ;

Kissinger, P ;

Diem, L ;

Crawford, JT .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (06) :2683-2685

[8] Treatment outcomes for HIV-uninfected patients with multidrug-resistant and extensively drug-resistant tuberculosis [J].

Kwon, Yong Soo ;

Kim, Yee Hyung ;

Suh, Gee Young ;

Chung, Man Pyo ;

Kim, Hojoong ;

Kwon, O. Jung ;

Choi, Yong Soo ;

Kim, Kwhanmien ;

Kim, Jhingook ;

Shim, Young Mog ;

Koh, Won-Jung .

CLINICAL INFECTIOUS DISEASES, 2008, 47 (04) :496-502

[9] Extensively drug resistant tuberculosis - A serious wake-up call for global health [J].

Lawn, Stephen D. ;

Wilkinson, Robert .

BRITISH MEDICAL JOURNAL, 2006, 333 (7568) :559-560

[10]

Mlambo CK, 2008, INT J TUBERC LUNG D, V12, P99

← 1 2 →