Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis

被引：30

作者：

Graybill, JR

Bocanegra, R

Najvar, LK

Hernandez, S

Larsen, RA

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Med, Div Infect Dis 7881, San Antonio, TX 78229 USA

[2] Univ So Calif, Dept Med, Div Infect Dis, Los Angeles, CA 90033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 07期

关键词：

D O I：

10.1128/AAC.47.7.2373-2375.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.

引用

页码：2373 / 2375

页数：3

共 7 条

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[2]

HECTOR RF, 1993, CLIN MICROBIOL REV, V6, P1

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