Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera). Part II: Biomimetic potential and applications

被引：93

作者：

Ehrlich, H. ^{[1
]}

Steck, E. ^{[2
]}

Ilan, M. ^{[3
]}

Maldonado, M. ^{[4
]}

Muricy, G. ^{[5
]}

Bavestrello, G. ^{[6
]}

Kljajic, Z. ^{[7
]}

Carballo, J. L. ^{[8
]}

Schiaparelli, S. ^{[9
]}

Ereskovsky, A. ^{[10
]}

Schupp, P. ^{[11
]}

Born, R. ^{[12
,13
]}

Worch, H. ^{[12
,13
]}

Bazhenov, V. V. ^{[14
]}

Kurek, D. ^{[15
]}

Varlamov, V. ^{[15
]}

Vyalikh, D. ^{[16
]}

Kummer, K. ^{[16
]}

Sivkov, V. V. ^{[17
]}

Molodtsov, S. L. ^{[16
]}

Meissner, H. ^{[18
]}

Richter, G. ^{[18
]}

Hunoldt, S. ^{[1
]}

Kammer, M. ^{[1
]}

Paasch, S. ^{[1
]}

Krasokhin, V. ^{[19
]}

Patzke, G. ^{[20
]}

Brunner, E. ^{[1
]}

Richter, W. ^{[2
]}

机构：

[1] Tech Univ Dresden, Inst Bioanalyt Chem, D-01069 Dresden, Germany

[2] Univ Klinikum Heidelberg, Dept Orthopadie Unfallchirurg & Paraplegiol, Forschungszentrum Expt Orthopadie, D-69118 Heidelberg, Germany

[3] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Zool, IL-69978 Tel Aviv, Israel

[4] Ctr Estudios Avanzados Blanes, Dept Marine Ecol, Blanes 17300, Girona, Spain

[5] Univ Fed Rio de Janeiro, Museu Nacl, Dept Invertebrados, BR-20940040 Rio De Janeiro, Brazil

[6] Univ Politecn Marche, Dipartimento Sci Mare, I-60131 Ancona, Italy

[7] Univ Montenegro, Inst Marine Biol, Kotor 85330, Montenegro

[8] Univ Nacl Autonoma Mexico, Estn Mazatlan, Inst Ciencias Mar & Limnol, Mazatlan 82040, Sin, Mexico

[9] Nat Hist Museum, I-16100 Genoa, Italy

[10] Aix Marseille Univ, CNRS, DIMAR, Ctr Oceanol Marseille,Stn Marine Endoume,UMR 6540, F-13007 Marseille, France

[11] UOG Stn, UOG Marine Lab, Mangilao, GU 96923 USA

[12] Tech Univ Dresden, Max Bergmann Ctr Biomat, D-01069 Dresden, Germany

[13] Tech Univ Dresden, Inst Mat Sci, D-01069 Dresden, Germany

[14] Far Eastern Natl Univ, Inst Chem & Appl Ecol, Vladivostok 690650, Russia

[15] Russian Acad Sci, Ctr Bioengn, Moscow 117312, Russia

[16] Tech Univ Dresden, Inst Solid State Phys, D-01069 Dresden, Germany

[17] Russian Acad Sci, Dept Math Komi SC UrD, Syktyvkar 167000, Russia

[18] Tech Univ Dresden, Carl Gustav Carus Univ Clin, D-01307 Dresden, Germany

[19] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia

[20] Univ Zurich, Inst Inorgan Chem, CH-8057 Zurich, Switzerland

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 47卷 / 02期

关键词：

Biochemistry; Biomineralization; Marine biotechnology; Materials science; Tissue engineering; BETA-CHITIN; COMPOSITE SCAFFOLDS;

D O I：

10.1016/j.ijbiomac.2010.05.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to evaluate the biomedical potential of three-dimensional chitinous scaffolds of poriferan origin, chondrocyte culturing experiments were performed. It was shown for the first time that freshly isolated chondrocytes attached well to the chitin scaffold and synthesized an extracellular matrix similar to that found in other cartilage tissue engineering constructs. Chitin scaffolds also supported deposition of a proteoglycan-rich extracellular matrix of chondrocytes seeded bioconstructs in an in vivo environment. We suggest that chitin sponge scaffolds, apart from the demonstrated biomedical applications, are highly optimized structures for use as filtering systems, templates for biomineralization as well as metallization in order to produce catalysts. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：141 / 145

页数：5

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