Exploration of β-turn scaffolding motifs as components of sialyl Lex mimetics and their relevance to P-selectin

被引：18

作者：

Hanessian, S

Huynh, HK

Reddy, GV

McNaughton-Smith, G

Ernst, B

Kolb, HC

Magnani, J

Sweeley, C

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

[2] Novartis Pharma Ltd, Basel, Switzerland

[3] Glyotech Corp, Rockville, MD 20850 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(98)00500-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Monocyclic and bicyclic lactam units representing P-turn surrogates were incorporated into a sialyl Le(X) structure by replacement of the natural sugar components. I;ow micromolar activity was found in a new P-selectin binding assay.(C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：2803 / 2808

页数：6

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