The helix-loop-helix gene SCL: Implicated in T-cell acute lymphoblastic leukaemia and in normal haematopoietic development

被引：14

作者：

Robb, L ^{[1
]}

Begley, CG ^{[1
]}

机构：

[1] ROYAL MELBOURNE HOSP, ROTARY BONE MARROW RES LABS, PARKVILLE, VIC 3050, AUSTRALIA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1996年 / 28卷 / 06期

关键词：

SCL; TAL-1; human leukaemia; gene targeting;

D O I：

10.1016/1357-2725(96)00006-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SCL gene encodes a member of the helix-loop-helix family of transcription factors and was first identified through its involvement in a chromosomal translocation in a human leukaemic cell line. SCL is now recognized to be aberrantly expressed in most human T-cell leukaemias. In around 25% of cases SCL overexpression is associated with identifiable chromosomal abnormalities but in other cases the mechanism of ectopic expression has not yet been identified. SCL is normally expressed in haematopoietic progenitor cells, erythroid cells, mast cells and megakaryocytes. Gene delivery experiments using haematopoietic cell lines and the recent creation of mice with a null mutation of the SCL gene have demonstrated that SCL plays a crucial role in haematopoietic commitment and differentiation. (C) 1996 Elsevier Science Ltd

引用

页码：609 / 618

页数：10

共 85 条

[71] ABSENCE OF BLOOD FORMATION IN MICE LACKING THE T-CELL LEUKEMIA ONCOPROTEIN TAL-1/SCL [J].

SHIVDASANI, RA ;

MAYER, EL ;

ORKIN, SH .

NATURE, 1995, 373 (6513) :432-434

[72]

STOCK W, 1995, CLIN CANCER RES, V1, P459

[73] THE SCL GENE-PRODUCT IS REGULATED BY AND DIFFERENTIALLY REGULATES CYTOKINE RESPONSES DURING MYELOID LEUKEMIC-CELL DIFFERENTIATION [J].

TANIGAWA, T ;

ELWOOD, N ;

METCALF, D ;

CARY, D ;

DELUCA, E ;

NICOLA, NA ;

BEGLEY, CG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (16) :7864-7868

[74]

TANIGAWA T, 1994, CELL GROWTH DIFFER, V5, P557

[75] AN EARLY HEMATOPOIETIC DEFECT IN MICE LACKING THE TRANSCRIPTION FACTOR GATA-2 [J].

TSAI, FY ;

KELLER, G ;

KUO, FC ;

WEISS, M ;

CHEN, JZ ;

ROSENBLATT, M ;

ALT, FW ;

ORKIN, SH .

NATURE, 1994, 371 (6494) :221-226

[76] THE LIM PROTEIN RBTN2 AND THE BASIC HELIX-LOOP-HELIX PROTEIN TAL1 ARE PRESENT IN A COMPLEX IN ERYTHROID-CELLS [J].

VALGEARCHER, VE ;

OSADA, H ;

WARREN, AJ ;

FORSTER, A ;

LI, J ;

BAER, R ;

RABBITTS, TH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (18) :8617-8621

[77]

VARTERASIAN M, 1993, CELL GROWTH DIFFER, V4, P885

[78]

VISVADER J, 1991, ONCOGENE, V6, P187

[79] THE E2A AND TAL-1 HELIX-LOOP-HELIX PROTEINS ASSOCIATE IN-VIVO AND ARE MODULATED BY ID PROTEINS DURING INTERLEUKIN-6-INDUCED MYELOID DIFFERENTIATION [J].

VORONOVA, AF ;

LEE, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5952-5956

[80] SPECIFIC IN-VIVO ASSOCIATION BETWEEN THE BHLH AND LIM PROTEINS IMPLICATED IN HUMAN T-CELL LEUKEMIA [J].

WADMAN, I ;

LI, JX ;

BASH, RO ;

FORSTER, A ;

OSADA, H ;

RABBITTS, TH ;

BAER, R .

EMBO JOURNAL, 1994, 13 (20) :4831-4839

← 1 2 3 4 5 6 7 8 9 →