Palladium-catalyzed α-arylation of oxindoles

被引：82

作者：

Durbin, Matthew J. ^{[1
]}

Willis, Michael C. ^{[2
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol800141t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalyst generated from Pd(dba)(2) and the bulky electron-rich phosphine ligand 2-(dicyclohexylphosphino)-2',4', 6'-tri-i-propyl-1 - 1'-biphenyl is effective for the alpha-arylation of oxindoles. Generation of the potassium-enolates of a range of oxindoles allows coupling with aryl chlorides, bromides, and triflates. Significant variation of the substitution pattern on both the oxindole and aryl halide is possible.

引用

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页码：1413 / 1415

页数：3

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