Mesenchymal stromal cell 'licensing': a multistep process

被引：293

作者：

Krampera, M. ^{[1
]}

机构：

[1] Univ Verona, Stem Cell Res Lab, Policlin GB Rossi, Dept Med,Sect Hematol, I-37134 Verona, Italy

来源：

LEUKEMIA | 2011年 / 25卷 / 09期

关键词：

mesenchymal stromal cells; licensing; immune regulation; HUMAN BONE-MARROW; VERSUS-HOST-DISEASE; ANTIGEN-PRESENTING CELL; SUPPRESS T-LYMPHOCYTE; TOLL-LIKE RECEPTORS; ADULT STEM-CELLS; INTERFERON-GAMMA; DENDRITIC CELLS; ADIPOSE-TISSUE; NITRIC-OXIDE;

D O I：

10.1038/leu.2011.108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects. Leukemia (2011) 25, 1408-1414; doi: 10.1038/leu.2011.108; published online 27 May 2011

引用

收藏

页码：1408 / 1414

页数：7

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