Mesenchymal stromal cell 'licensing': a multistep process

被引：293

作者：

Krampera, M. ^{[1
]}

机构：

[1] Univ Verona, Stem Cell Res Lab, Policlin GB Rossi, Dept Med,Sect Hematol, I-37134 Verona, Italy

来源：

LEUKEMIA | 2011年 / 25卷 / 09期

关键词：

mesenchymal stromal cells; licensing; immune regulation; HUMAN BONE-MARROW; VERSUS-HOST-DISEASE; ANTIGEN-PRESENTING CELL; SUPPRESS T-LYMPHOCYTE; TOLL-LIKE RECEPTORS; ADULT STEM-CELLS; INTERFERON-GAMMA; DENDRITIC CELLS; ADIPOSE-TISSUE; NITRIC-OXIDE;

D O I：

10.1038/leu.2011.108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects. Leukemia (2011) 25, 1408-1414; doi: 10.1038/leu.2011.108; published online 27 May 2011

引用

收藏

页码：1408 / 1414

页数：7

相关论文

共 106 条

[11] Human mesenchymal stem cells modulate B-cell functions [J].

Corcione, A ;

Benvenuto, F ;

Ferretti, E ;

Giunti, D ;

Cappiello, V ;

Cazzanti, F ;

Risso, M ;

Gualandi, F ;

Mancardi, GL ;

Pistoia, V ;

Uccelli, A .

BLOOD, 2006, 107 (01) :367-372

[12] Mesenchymal stem cells for graft-versus-host disease:: Close encounters with T cells [J].

Dazzi, Francesco ;

Marelli-Berg, Federica M. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (06) :1479-1482

[13] The role of mesenchymal stem cells in haemopoiesis [J].

Dazzi, Francesco ;

Ramasamy, Rajesh ;

Glennie, Sarah ;

Jones, Simon P. ;

Roberts, Irene .

BLOOD REVIEWS, 2006, 20 (03) :161-171

[14] Comparison of multi-lineage cells from human adipose tissue and bone marrow [J].

De Ugarte, DA ;

Morizono, K ;

Elbarbary, A ;

Alfonso, Z ;

Zuk, PA ;

Zhu, M ;

Dragoo, JL ;

Ashjian, P ;

Thomas, B ;

Benhaim, P ;

Chen, I ;

Fraser, J ;

Hedrick, MH .

CELLS TISSUES ORGANS, 2003, 174 (03) :101-109

[15] Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential [J].

DelaRosa, Olga ;

Lombardo, Eleuterio .

MEDIATORS OF INFLAMMATION, 2010, 2010

[16] Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli [J].

Di Nicola, M ;

Carlo-Stella, C ;

Magni, M ;

Milanesi, M ;

Longoni, PD ;

Matteucci, P ;

Grisanti, S ;

Gianni, AM .

BLOOD, 2002, 99 (10) :3838-3843

[17] Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism [J].

Djouad, Farida ;

Charbonnier, Louis-Marie ;

Bouffi, Carine ;

Louis-Plence, Pascale ;

Bony, Claire ;

Apparailly, Florence ;

Cantos, Celine ;

Jorgensen, Christian ;

Noel, Daniele .

STEM CELLS, 2007, 25 (08) :2025-2032

[18] IFN-γ and TNF-α differentially regulate immunomodulation by murine mesenchymal stem cells [J].

English, Karen ;

Barry, Frank P. ;

Field-Corbett, Ciara P. ;

Mahon, Bernard P. .

IMMUNOLOGY LETTERS, 2007, 110 (02) :91-100

[19] Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties [J].

Francois, Moira ;

Romieu-Mourez, Raphaelle ;

Stock-Martineau, Sophie ;

Boivin, Marie-Noelle ;

Bramson, Jonathan L. ;

Galipeau, Jacques .

BLOOD, 2009, 114 (13) :2632-2638

[20] Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice [J].

Galie, M. ;

Konstantinidou, G. ;

Peroni, D. ;

Scambi, I. ;

Marchini, C. ;

Lisi, V. ;

Krampera, M. ;

Magnani, P. ;

Merigo, F. ;

Montani, M. ;

Boschi, F. ;

Marzola, P. ;

Orru, R. ;

Farace, P. ;

Sbarbati, A. ;

Amici, A. .

ONCOGENE, 2008, 27 (18) :2542-2551

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