RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity

被引：112

作者：

Yoneyama, Mitsutoshi

Fujita, Takashi ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Genet Mol Lab, Kyoto 6068507, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Mol Cell Biol Lab, Kyoto 6068507, Japan

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2007年 / 18卷 / 5-6期

关键词：

type I interferon; RIG-I; RNA helicase; innate immunity;

D O I：

10.1016/j.cytogfr.2007.06.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viral infection is detected by cellular sensors as foreign nucleic acid and initiates innate antiviral responses, including the activation of type I interferon (IFN) and proinflammatory cytokines. Recent advances in cytoplasmic virus sensors highlight their essential role in the induction of innate immunity. Moreover, it is intriguing to understand how they can discriminate innate RNA from viral foreign RNA. In this mini-review, we focus on these cytoplasmic virus sensors, termed retinoic acid inducible gene-I (RIG-I)-like receptors (RLRs), and discuss their function in the innate immune system. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：545 / 551

页数：7

相关论文

共 62 条

[31] Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation [J].

Mariathasan, Sanjeev ;

Monack, Denise M. .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (01) :31-40

[32] Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7 [J].

Marié, I ;

Durbin, JE ;

Levy, DE .

EMBO JOURNAL, 1998, 17 (22) :6660-6669

[33] IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts [J].

McWhirter, SM ;

Fitzgerald, KA ;

Rosains, J ;

Rowe, DC ;

Golenbock, DT ;

Maniatis, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :233-238

[34] Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus [J].

Meylan, E ;

Curran, J ;

Hofmann, K ;

Moradpour, D ;

Binder, M ;

Bartenschlager, R ;

Tschopp, R .

NATURE, 2005, 437 (7062) :1167-1172

[35] Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza a virus [J].

Mibayashi, Masaki ;

Martinez-Sobrido, Luis ;

Loo, Yueh-Ming ;

Cardenas, Washington B. ;

Gale, Michael, Jr. ;

Garcia-Sastre, Adolfo .

JOURNAL OF VIROLOGY, 2007, 81 (02) :514-524

[36] REGULATED EXPRESSION OF A GENE ENCODING A NUCLEAR FACTOR, IRF-1, THAT SPECIFICALLY BINDS TO IFN-BETA-GENE REGULATORY ELEMENTS [J].

MIYAMOTO, M ;

FUJITA, T ;

KIMURA, Y ;

MARUYAMA, M ;

HARADA, H ;

SUDO, Y ;

MIYATA, T ;

TANIGUCHI, T .

CELL, 1988, 54 (06) :903-913

[37] IFNβ induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein [J].

Opitz, Bastian ;

Rejaibi, Amira ;

Dauber, Bianca ;

Eckhard, Jamina ;

Vinzing, Maya ;

Schmeck, Bernd ;

Hippenstiel, Stefan ;

Suttorp, Norbert ;

Wolff, Thorsten .

CELLULAR MICROBIOLOGY, 2007, 9 (04) :930-938

[38]

Paul Aniko V., 2002, P227

[39] Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection [J].

Perry, AK ;

Chow, EK ;

Goodnough, JB ;

Yeh, WC ;

Cheng, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (12) :1651-1658

[40] RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates [J].

Pichlmair, Andreas ;

Schulz, Oliver ;

Tan, Choon Ping ;

Naslund, Tanja I. ;

Liljestrom, Peter ;

Weber, Friedemann ;

Sousa, Caetano Reis E. .

SCIENCE, 2006, 314 (5801) :997-1001

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