RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity

被引：112

作者：

Yoneyama, Mitsutoshi

Fujita, Takashi ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Genet Mol Lab, Kyoto 6068507, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Mol Cell Biol Lab, Kyoto 6068507, Japan

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2007年 / 18卷 / 5-6期

关键词：

type I interferon; RIG-I; RNA helicase; innate immunity;

D O I：

10.1016/j.cytogfr.2007.06.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viral infection is detected by cellular sensors as foreign nucleic acid and initiates innate antiviral responses, including the activation of type I interferon (IFN) and proinflammatory cytokines. Recent advances in cytoplasmic virus sensors highlight their essential role in the induction of innate immunity. Moreover, it is intriguing to understand how they can discriminate innate RNA from viral foreign RNA. In this mini-review, we focus on these cytoplasmic virus sensors, termed retinoic acid inducible gene-I (RIG-I)-like receptors (RLRs), and discuss their function in the innate immune system. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：545 / 551

页数：7

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