Peptide- and Protein-Based Hydrogels

被引：446

作者：

Jonker, Anika M. ^{[1
]}

Loewik, Dennis W. P. M. ^{[1
]}

van Hest, Jan C. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands

来源：

CHEMISTRY OF MATERIALS | 2012年 / 24卷 / 05期

关键词：

hydrogels; peptides; proteins; polymers; tissue engineering; ELASTIN-LIKE POLYPEPTIDES; SITU CROSS-LINKING; CO-PEG NETWORKS; BIOMEDICAL APPLICATIONS; REVERSIBLE HYDROGELS; GLOBULAR PROTEIN; CELL-ADHESIVE; GROWTH-FACTOR; IN-VITRO; PART;

D O I：

10.1021/cm202640w

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Hydrogels are polymeric networks, capable of absorbing large amounts of water and biological fluids. They are insoluble due to the presence of chemical or physical cross-links between the constituents. Hydrogels are promising materials for use as injectable biomaterials due to their high water content, tunable viscoelasticity, and biocompatibility. Peptides and proteins are important building blocks in the design of hydrogels, since they are easily degraded by the body and display a high biocompatibility. This review aims to. give an overview of hydrogels in which peptides and proteins are structural elements of the polymer network. The review starts with hydrogels derived from naturally occurring structural proteins, followed by all-protein and peptide-based synthetic systems. Next, hybrid hydrogels composed of synthetic polymeric and peptide structural elements will be discussed. The potential of these hydrogels is illustrated with applications that are mainly derived from the field of tissue engineering.

引用

页码：759 / 773

页数：15

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