Signaling of lysophosphatidic acid-evoked chloride current: calcium release from inositol trisphosphate-sensitive store

被引：11

作者：

Kakizawa, K ^{[1
]}

Nomura, H ^{[1
]}

Yoshida, A ^{[1
]}

Ueda, H ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol & Neurosci, Nagasaki 8528521, Japan

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 61卷 / 1-2期

关键词：

lysophasphatidic acid; phospholipase C; araguspongine E/xestospongin C; inositol trisphosphate receptor; signal transduction; Xenopus oocyte;

D O I：

10.1016/S0169-328X(98)00229-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Xenopus oocytes, lysophosphatidic acid (LPA) evoked inward currents at the holding potential of -60 mV, which were quickly desensitized upon repeated challenges of the compound at 10 nM or I mu M. This desensitization was prevented by pretreatment with protein kinase A inhibitor or recovered by its post-treatment, but not by the pretreatment with an inhibitor of protein kinase C or calmodulin kinase II. From pharmacological studies, the LPA-evoked currents were found to be mediated by phospholipase C, calcium-mobilization from thapsigargin-sensitive Ca2+ stores, araguspongine E-sensitive inositol trisphosphate receptor, and calcium-dependent chloride channels. (C) 1998 Elsevier Science B.V, All rights reserved.

引用

页码：232 / 237

页数：6

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