Supercritical fluid chromatography of paclitaxel

被引：17

作者：

Jagota, NK

Nair, JB

Frazer, R

Klee, M

Wang, MZ

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,NEW BRUNSWICK,NJ 08903

[2] HEWLETT PACKARD CORP,WILMINGTON,DE 19808

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 721卷 / 02期

关键词：

D O I：

10.1016/0021-9673(95)00778-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The analysis of paclitaxel and related compounds was investigated using supercritical fluid chromatography (SFC), The separation of paclitaxel and five related taxanes was compared on two SFC instruments, The typical analysis lime was 20 min on system I and 4 min on system II. Based on this, SFC system II was selected for further studies and a separation of paclitaxel from fifteen of its impurities br degradation products was achieved in about 35 min.

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收藏

页码：315 / 322

页数：8

相关论文

共 13 条

[1] SEPARATION OF DRUGS BY PACKED-COLUMN SUPERCRITICAL-FLUID CHROMATOGRAPHY .1. PHENOTHIAZINE ANTIPSYCHOTICS [J].

BERGER, TA ;

WILSON, WH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 83 (03) :281-286

[2] SEPARATION OF DRUGS BY PACKED-COLUMN SUPERCRITICAL-FLUID CHROMATOGRAPHY .2. ANTIDEPRESSANTS [J].

BERGER, TA ;

WILSON, WH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 83 (03) :287-290

[3] SUPERCRITICAL FLUID CHROMATOGRAPHY OF POLAR DRUGS USING SMALL-PARTICLE PACKED-COLUMNS WITH MASS-SPECTROMETRIC DETECTION [J].

CROWTHER, JB ;

HENION, JD .

ANALYTICAL CHEMISTRY, 1985, 57 (13) :2711-2716

[4] SEPARATION OF TAXOL FROM RELATED TAXANES IN TAXUS-BREVIFOLIA EXTRACTS BY ISOCRATIC ELUTION REVERSED-PHASE MICROCOLUMN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

HARVEY, SD ;

CAMPBELL, JA ;

KELSEY, RG ;

VANCE, NC .

JOURNAL OF CHROMATOGRAPHY, 1991, 587 (02) :300-305

[5]

HEATON DM, 1993, HRC-J HIGH RES CHROM, V16, P666, DOI 10.1002/jhrc.1240161109

[6] SEPARATION OF NONSTEROIDAL ANTIINFLAMMATORY AGENTS USING SUPERCRITICAL FLUID CHROMATOGRAPHY [J].

JAGOTA, NK ;

STEWART, JT .

JOURNAL OF CHROMATOGRAPHY, 1992, 604 (02) :255-260

[7] ANALYSIS OF DIAZEPAM AND CHLORDIAZEPOXIDE AND THEIR RELATED-COMPOUNDS USING SUPERCRITICAL FLUID CHROMATOGRAPHY [J].

JAGOTA, NK ;

STEWART, JT .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1992, 15 (14) :2429-2443

[8]

LATER DW, 1988, LC GC, V4, P992

[9] ANALYSIS OF VETERINARY DRUGS USING SUPERCRITICAL FLUID CHROMATOGRAPHY AND SUPERCRITICAL FLUID CHROMATOGRAPHY MASS-SPECTROMETRY [J].

PERKINS, JR ;

GAMES, DE ;

STARTIN, JR ;

GILBERT, J .

JOURNAL OF CHROMATOGRAPHY, 1991, 540 (1-2) :257-270

[10]

SMITH MS, 1994, J CHROMATOGR A, V684, P402