Intestinal myoribroblasts and immune tolerance

被引：13

作者：

Saada, JI

Barrera, CA

Reyes, VE

Adegboyega, PA

Suarez, G

Tamerisa, RA

Pang, KF

Bland, DA

Mifflin, RC

Di Mari, JF

Powell, DW

机构：

[1] Univ Texas, Med Branch, Dept Internal Med, Div Gastroenterol, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, Dept Cellular Physiol & Mol Biophys, Galveston, TX 77555 USA

[3] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

[4] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[5] Univ Texas, Med Branch, Dept Pediat, Galveston, TX 77555 USA

来源：

ORAL TOLERANCE: NEW INSIGHTS AND PROSPECTS FOR CLINICAL APPLICATION | 2004年 / 1029卷

关键词：

mucosal immunity; immune tolerance; antigen-presenting cell; HLA-DR; fibroblastic sheath;

D O I：

10.1196/annals.1309.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4(+) T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.

引用

页码：379 / 381

页数：3

共 4 条

[1] Nature and function of gastrointestinal antigen-presenting cells [J].