Blood Purification Using Functionalized Core/Shell Nanomagnets

被引:102
作者
Herrmann, Inge K. [1 ]
Urner, Martin [2 ,3 ]
Koehler, Fabian M. [1 ]
Hasler, Melanie [2 ,3 ]
Roth-Z'Graggen, Birgit [2 ,3 ]
Grass, Robert N. [1 ]
Ziegler, Urs [4 ]
Beck-Schimmer, Beatrice [2 ,3 ]
Stark, Wendelin J. [1 ]
机构
[1] ETH, Dept Chem & Appl Biosci, Inst Chem & Bioengn, CH-8093 Zurich, Switzerland
[2] Univ Zurich Hosp, Inst Anesthesiol, CH-8091 Zurich, Switzerland
[3] Univ Zurich, Inst Physiol, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland
[4] Univ Zurich, Ctr Microscopy & Image Anal, Zurich, Switzerland
关键词
in vivo extraction; magnetochemistry; nanomedicine; nanoparticles; therapy; NANOPARTICLES; MICROPARTICLES; INTERLEUKIN-6; REMOVAL; SEPSIS; CELLS;
D O I
10.1002/smll.201000438
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Injection of functional nanomagnets in human blood enables selective removal of disease-causing metals, overdosed drugs, and proteins at the (sub-)nanomolar level. This direct in vivo extraction provides a powerful alternative to classical pharmaceutical treatments as disease-causing agents are removed from the organism rather than treating symptoms from exposure. A number of clinically relevant assays demonstrate blood compatibility of the functional nanomagnets. (Figure Presented.) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:1388 / 1392
页数:5
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