Blood Purification Using Functionalized Core/Shell Nanomagnets

被引：102

作者：

Herrmann, Inge K. ^{[1
]}

Urner, Martin ^{[2
,3
]}

Koehler, Fabian M. ^{[1
]}

Hasler, Melanie ^{[2
,3
]}

Roth-Z'Graggen, Birgit ^{[2
,3
]}

Grass, Robert N. ^{[1
]}

Ziegler, Urs ^{[4
]}

Beck-Schimmer, Beatrice ^{[2
,3
]}

Stark, Wendelin J. ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, Inst Chem & Bioengn, CH-8093 Zurich, Switzerland

[2] Univ Zurich Hosp, Inst Anesthesiol, CH-8091 Zurich, Switzerland

[3] Univ Zurich, Inst Physiol, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

[4] Univ Zurich, Ctr Microscopy & Image Anal, Zurich, Switzerland

来源：

SMALL | 2010年 / 6卷 / 13期

关键词：

in vivo extraction; magnetochemistry; nanomedicine; nanoparticles; therapy; NANOPARTICLES; MICROPARTICLES; INTERLEUKIN-6; REMOVAL; SEPSIS; CELLS;

D O I：

10.1002/smll.201000438

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Injection of functional nanomagnets in human blood enables selective removal of disease-causing metals, overdosed drugs, and proteins at the (sub-)nanomolar level. This direct in vivo extraction provides a powerful alternative to classical pharmaceutical treatments as disease-causing agents are removed from the organism rather than treating symptoms from exposure. A number of clinically relevant assays demonstrate blood compatibility of the functional nanomagnets. (Figure Presented.) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1388 / 1392

页数：5

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