Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice

被引：100

作者：

Schmitt, WB

Sprengel, R

Mack, V

Draft, RW

Seeburg, PH

Deacon, RMJ

Rawlins, JNP

Bannerman, DM

机构：

[1] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England

[2] Max Planck Inst Med Res, Dept Mol Neurobiol, D-69120 Heidelberg, Germany

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nn1412

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1 have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTR This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing.

引用

收藏

页码：270 / 272

页数：3

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