Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

被引：95

作者：

Mack, V

Burnashev, N

Kaiser, KMM

Rozov, A

Jensen, V

Hvalby, O

Sakmann, B

Seeburg, PH

Sprengel, R

机构：

[1] Max Planck Inst Med Res, Dept Mol Neurobiol, D-69120 Heidelberg, Germany

[2] Max Planck Inst Med Res, Dept Cell Physiol, D-69120 Heidelberg, Germany

[3] Univ Oslo, Inst Basic Med Sci, Dept Physiol, N-0462 Oslo, Norway

来源：

SCIENCE | 2001年 / 292卷 / 5526期

关键词：

D O I：

10.1126/science.1059365

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GLuR-A) subunit. In GLuR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-tagged GluRA, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A(-/-) mice when (GFP)GluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP.

引用

页码：2501 / 2504

页数：4

共 16 条

[1] COREGULATION OF 2 GENE ACTIVITIES BY TETRACYCLINE VIA A BIDIRECTIONAL PROMOTER [J].