Clearing the brain's amyloid cobwebs

被引：479

作者：

Selkoe, DJ ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

NEURON | 2001年 / 32卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(01)00475-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Elevated cerebral levels of amyloid beta -protein occur universally in Alzheimer's disease, yet only a few patients show evidence of increased A beta production. Therefore, defects in proteases that degrade A beta could underlie some or many cases of familial and sporadic AD. This previously neglected topic has begun receiving serious attention. Understanding how proteolysis regulates A beta levels in the cerebral cortex has implications for both the pathogenesis and the treatment of this protean disorder.

引用

页码：177 / 180

页数：4

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