MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics

被引:37
作者
Malhi, Ripan S. [1 ,2 ]
Sickler, Brad [5 ]
Lin, Dawei [5 ]
Satkoski, Jessica [4 ]
Tito, Raul Y. [1 ]
George, Debbie [4 ]
Kanthaswamy, Sreetharan [3 ]
Smith, David Glenn [3 ,4 ]
机构
[1] Univ Illinois, Dept Anthropol, Urbana, IL 61801 USA
[2] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA
[3] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA
[4] Univ Calif Davis, Dept Anthropol, Davis, CA 95616 USA
[5] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA
来源
PLOS ONE | 2007年 / 2卷 / 05期
关键词
D O I
10.1371/journal.pone.0000438
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We developed a novel method for identifying SNPs widely distributed throughout the coding and non-coding regions of a genome. The method uses large-scale parallel pyrosequencing technology in combination with bioinformatics tools. We used this method to generate approximately 23,000 candidate SNPs throughout the Macaca mulatta genome. We estimate that over 60% of the SNPs will be of high frequency and useful for mapping QTLs, genetic management, and studies of individual relatedness, whereas other less frequent SNPs may be useful as population specific markers for ancestry identification. We have created a web resource called MamuSNP to view the SNPs and associated information online. This resource will also be useful for researchers using a wide variety of Macaca species in their research.
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页数:5
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