2011 Rita Schaffer Lecture: Nanoparticles for Intracellular Nucleic Acid Delivery

被引：17

作者：

Green, Jordan J. ^{[1
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机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Wilmer Eye Inst,Inst Nanobiotechnol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Translat Tissue Engn Ctr, Baltimore, MD 21231 USA

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2012年 / 40卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Biomaterials; Gene delivery; Nanoparticle; DNA; siRNA; GENE DELIVERY; POLY(AMIDO AMINE)S; POLY(BETA-AMINO ESTERS); CATIONIC POLYMERS; STEM-CELLS; THERAPY; DNA; VECTORS; TRANSFECTION; ENDOSOMES;

D O I：

10.1007/s10439-012-0550-3

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Nanoparticles are a promising technology for delivery of new types of therapeutics. A polymer library approach has allowed engineering of polymeric particles that are particularly effective for the delivery of DNA and siRNA to human cells. Certain chemical structural motifs, degradable linkages, hydrophobicity, and biophysical properties are key for successful intracellular delivery. Small differences to biomaterial structure, and especially the type of degradable linkage in the polymers, can be critical for successful delivery of siRNA vs. DNA. Furthermore, subtle changes to biomaterial structure can facilitate cell-type gene delivery specificity between human brain cancer cells and healthy cells as well as between human retinal endothelial cells and epithelial cells. These polymeric nanoparticles are effective for nucleic acid delivery in a broad range of human cell types and have applications to regenerative medicine, ophthalmology, and cancer among many other biomedical research areas.

引用

页码：1408 / 1418

页数：11

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