14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans

被引：14

作者：

Araiz, Caroline ^{[1
]}

Chateau, Marie-Therese ^{[1
,2
]}

Galas, Simon ^{[1
,2
]}

机构：

[1] CRBM CNRS, F-34293 Montpellier 5, France

[2] Univ Montpellier I, Fac Pharm, F-34093 Montpellier 5, France

来源：

EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 06期

关键词：

C; elegans; ageing; Insulin/IGF-1/DAF-2; FOXO/DAF-16; 14-3-3/ftt1/ftt2;

D O I：

10.1016/j.exger.2008.03.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stressresponsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-76 regulatory pathway in promoting life expectancy of growing old worms. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：505 / 519

页数：15

共 48 条

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The metabolic response of heterotrophic Arabidopsis cells to oxidative stress [J].