Characterization of microRNA-regulated protein-protein interaction network

被引：85

作者：

Hsu, Chun-Wei ^{[1
]}

Juan, Hsueh-Fen ^{[2
]}

Huang, Hsuan-Cheng ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Biomed Informat, Ctr Syst & Synthet Biol, Taipei 112, Taiwan

[2] Natl Taiwan Univ, Dept Life Sci, Inst Mol & Cellular Biol, Grad Inst Biomed Elect & Bioinformat,Ctr Syst Bio, Taipei 10764, Taiwan

来源：

PROTEOMICS | 2008年 / 8卷 / 10期

关键词：

microRNA; network topology; protein-protein interaction network;

D O I：

10.1002/pmic.200701004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We have performed topological analysis to elucidate the global correlation between microRNA (miRNA) regulation and protein-protein interaction network in human. The analysis showed that target genes of individual miRNA tend to be hubs and bottlenecks in the network. While proteins directly regulated by miRNA might not form a network module themselves, the miRNA-target genes and their interacting neighbors jointly showed significantly higher modularity. Ourfindings shed light on how miRNA may regulate the protein interaction network.

引用

页码：1975 / 1979

页数：5

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