共 100 条
Plasmacytoid dendritic cells and the regulation of immunoglobulin heavy chain class switching
被引:47
作者:

Cerutti, A
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机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Qiao, XG
论文数: 0 引用数: 0
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机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

He, B
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h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA
机构:
[1] Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA
[2] Cornell Univ, Weill Med Coll, Grad Program Immunol & Microbial Pathogenesis, New York, NY 10021 USA
关键词:
adaptive immunity;
antibody production;
B cell;
class switching;
dendritic cell;
innate immunity;
D O I:
10.1111/j.1440-1711.2005.01389.x
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
By substituting the heavy chain constant region of IgM and IgD with that of IgG, IgA or IgE, immunoglobulin class switching endows antibodies with novel effector functions that enhance the ability of the immune system to effectively clear invading pathogens. Plasmacytoid dendritic cells critically link innate immunity with adaptive immunity by producing massive amounts of type 1 IFN in response to viruses. We have recently found that type 1 IFN triggers class switching by inducing myeloid dendritic cells to upregulate the expression of BAFF and APRIL, two powerful B cell-activating molecules. In this paper, we propose that IFN-producing plasmacytoid dendritic cells modulate class switching by activating B cells through both T cell-dependent and T cell-independent pathways. A better understanding of these pathways may facilitate the development of novel antiviral vaccine strategies and aid in identifying new therapies for antibody-mediated autoimmune disorders, such as lupus.
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页码:554 / 562
页数:9
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共 100 条
[1]
GENERATION OF MEMORY B-CELLS AND PLASMA-CELLS IN-VITRO
[J].
ARPIN, C
;
DECHANET, J
;
VANKOOTEN, C
;
MERVILLE, P
;
GROUARD, G
;
BRIERE, F
;
BANCHEREAU, J
;
LIU, YJ
.
SCIENCE,
1995, 268 (5211)
:720-722

ARPIN, C
论文数: 0 引用数: 0
h-index: 0
机构:
SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE

DECHANET, J
论文数: 0 引用数: 0
h-index: 0
机构:
SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE

VANKOOTEN, C
论文数: 0 引用数: 0
h-index: 0
机构:
SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE

MERVILLE, P
论文数: 0 引用数: 0
h-index: 0
机构:
SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE

GROUARD, G
论文数: 0 引用数: 0
h-index: 0
机构:
SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE

BRIERE, F
论文数: 0 引用数: 0
h-index: 0
机构:
SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE

BANCHEREAU, J
论文数: 0 引用数: 0
h-index: 0
机构:
SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE

LIU, YJ
论文数: 0 引用数: 0
h-index: 0
机构:
SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE SCHERING PLOUGH CORP, IMMUNOL RES LAB, F-69571 DARDILLY, FRANCE
[2]
Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology
[J].
Asselin-Paturel, C
;
Boonstra, A
;
Dalod, M
;
Durand, I
;
Yessaad, N
;
Dezutter-Dambuyant, C
;
Vicari, A
;
O'Garra, A
;
Biron, C
;
Brière, F
;
Trinchieri, G
.
NATURE IMMUNOLOGY,
2001, 2 (12)
:1144-1150

Asselin-Paturel, C
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

Boonstra, A
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

论文数: 引用数:
h-index:
机构:

Durand, I
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

Yessaad, N
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

Dezutter-Dambuyant, C
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

Vicari, A
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

O'Garra, A
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

Biron, C
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

Brière, F
论文数: 0 引用数: 0
h-index: 0
机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France

Trinchieri, G
论文数: 0 引用数: 0
h-index: 0
机构:
Schering Plough Corp, Lab Immunol Res, Dardilly, France Schering Plough Corp, Lab Immunol Res, Dardilly, France
[3]
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
[J].
Avery, DT
;
Kalled, SL
;
Ellyard, JI
;
Ambrose, C
;
Bixler, SA
;
Thien, M
;
Brink, R
;
Mackay, F
;
Hodgkin, PD
;
Tangye, SG
.
JOURNAL OF CLINICAL INVESTIGATION,
2003, 112 (02)
:286-297

Avery, DT
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Kalled, SL
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Ellyard, JI
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Ambrose, C
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Bixler, SA
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Thien, M
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Brink, R
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Mackay, F
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Hodgkin, PD
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

Tangye, SG
论文数: 0 引用数: 0
h-index: 0
机构: Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia
[4]
Blood dendritic cells interact with splenic marginal zone B cells to initiate T-Independent immune responses
[J].
Balázs, M
;
Martin, F
;
Zhou, T
;
Kearney, JF
.
IMMUNITY,
2002, 17 (03)
:341-352

Balázs, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA

Martin, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA

Zhou, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA

Kearney, JF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA
[5]
Immunobiology of dendritic cells
[J].
Banchereau, J
;
Briere, F
;
Caux, C
;
Davoust, J
;
Lebecque, S
;
Liu, YT
;
Pulendran, B
;
Palucka, K
.
ANNUAL REVIEW OF IMMUNOLOGY,
2000, 18
:767-+

Banchereau, J
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Inst Immunol Res, Dallas, TX 75204 USA Baylor Inst Immunol Res, Dallas, TX 75204 USA

Briere, F
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Caux, C
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Davoust, J
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Lebecque, S
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Liu, YT
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Pulendran, B
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Palucka, K
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA
[6]
Dendritic cells and the control of immunity
[J].
Banchereau, J
;
Steinman, RM
.
NATURE,
1998, 392 (6673)
:245-252

Banchereau, J
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Res Inst, Baylor Inst Immunol, Dallas, TX 75246 USA

Steinman, RM
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Res Inst, Baylor Inst Immunol, Dallas, TX 75246 USA
[7]
The mechanism and regulation of chromosomal V(D)J recombination
[J].
Bassing, CH
;
Swat, W
;
Alt, FW
.
CELL,
2002, 109
:S45-S55

Bassing, CH
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp, Ctr Blood Res, Howard Hughes Med Inst, Boston, MA 02115 USA Childrens Hosp, Ctr Blood Res, Howard Hughes Med Inst, Boston, MA 02115 USA

Swat, W
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp, Ctr Blood Res, Howard Hughes Med Inst, Boston, MA 02115 USA Childrens Hosp, Ctr Blood Res, Howard Hughes Med Inst, Boston, MA 02115 USA

Alt, FW
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp, Ctr Blood Res, Howard Hughes Med Inst, Boston, MA 02115 USA Childrens Hosp, Ctr Blood Res, Howard Hughes Med Inst, Boston, MA 02115 USA
[8]
Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type IFN
[J].
Bekeredjian-Ding, IB
;
Wagner, M
;
Hornung, V
;
Giese, T
;
Schnurr, M
;
Endres, S
;
Hartmann, G
.
JOURNAL OF IMMUNOLOGY,
2005, 174 (07)
:4043-4050

Bekeredjian-Ding, IB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Klin Innenstadt, Klin Pharmakol Abt, D-80336 Munich, Germany

Wagner, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Klin Innenstadt, Klin Pharmakol Abt, D-80336 Munich, Germany

Hornung, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Klin Innenstadt, Klin Pharmakol Abt, D-80336 Munich, Germany

论文数: 引用数:
h-index:
机构:

Schnurr, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Klin Innenstadt, Klin Pharmakol Abt, D-80336 Munich, Germany

Endres, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Klin Innenstadt, Klin Pharmakol Abt, D-80336 Munich, Germany

Hartmann, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Klin Innenstadt, Klin Pharmakol Abt, D-80336 Munich, Germany
[9]
Autoreactivity by design: Innate B and T lymphocytes
[J].
Bendelac, A
;
Bonneville, M
;
Kearney, JF
.
NATURE REVIEWS IMMUNOLOGY,
2001, 1 (03)
:177-186

Bendelac, A
论文数: 0 引用数: 0
h-index: 0
机构:
Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

Bonneville, M
论文数: 0 引用数: 0
h-index: 0
机构: Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

Kearney, JF
论文数: 0 引用数: 0
h-index: 0
机构: Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
[10]
Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
[J].
Bennett, L
;
Palucka, AK
;
Arce, E
;
Cantrell, V
;
Borvak, J
;
Banchereau, J
;
Pascual, V
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2003, 197 (06)
:711-723

Bennett, L
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Palucka, AK
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Arce, E
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Cantrell, V
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Borvak, J
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Banchereau, J
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA

Pascual, V
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Inst Immunol Res, Dallas, TX 75204 USA