A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus

被引：32

作者：

Schnabel, R ^{[1
]}

Palmer, MJ

Kilpatrick, IC

Collingridge, GL

机构：

[1] Univ Bristol, Sch Med Sci, Dept Anat, Bristol BS8 1TD, Avon, England

[2] Knoll Pharmaceut, Res & Dev, Nottingham NG1 1GF, England

来源：

NEUROPHARMACOLOGY | 1999年 / 38卷 / 04期

关键词：

glutamate; metabotropic glutamate (mGlu) receptor; (RS)-3,5-dihydroxyphenylglycine (DHPG); hippocampal slice; long-term depression; synaptic plasticity;

D O I：

10.1016/S0028-3908(98)00229-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have shown previously that activation of mGlu receptors using a group I specific mGlu receptor agonist, (RS)-3,5-dihydroxyphenylglycine (DHPG), can induce long-term depression (LTD) in the CA1 region of the hippocampus (Palmer et al., 1997). We now report that DHPG-induced LTD is facilitated by treatment with KN-62, an inhibitor of certain Ca2+ /calmodulin-dependent protein kinases (CaMKs), including CaMKII. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：605 / 608

页数：4

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