Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

被引：372

作者：

Bush, Karen ^{[1
]}

机构：

[1] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2010年 / 13卷 / 05期

关键词：

KLEBSIELLA-PNEUMONIAE STRAINS; NEW-YORK-CITY; PSEUDOMONAS-AERUGINOSA; MOLECULAR CHARACTERIZATION; KPC-2; CARBAPENEMASE; ESCHERICHIA-COLI; CLINICAL ISOLATE; CLONAL SPREAD; PLASMID; EMERGENCE;

D O I：

10.1016/j.mib.2010.09.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Resistance to beta-lactams and other antibiotics in the Enterobacteriaceae is frequently associated with plasmidic resistance determinants that are easily transferred among species. beta-Lactamase-mediated resistance is increasingly associated with plasmid-encoded extended-spectrum beta-lactamases (ESBLs) and carbapenemases, specifically the CTX-M family of ESBLs, the KPC family of serine carbapenemases, and the VIM, IMP, and NDM-1 metallo-beta-lactamases. Although clonal dispersion of resistant isolates was seen initially, more diverse genetic platforms are being observed as variations of mobile elements are transferred worldwide. These enzymes are now appearing in multiple combinations of ESBLs and carbapenemases, thereby conferring resistance to virtually all beta-lactam antibiotics.

引用

收藏

页码：558 / 564

页数：7

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