Usefulness of S100A12 as a prognostic biomarker for adverse events in patients with heart failure

Objectives: S100A12 has been proposed as a novel pivotal factor in inflammation produced by granulocytes. The purpose of this study was to investigate the relationship between S100A12 and chronic heart failure (CHF). Design and methods: One hundred and seventy-seven patients with CHF and 66 subjects without CHF were included in this study. Plasma levels of S100A12 and high sensitivity C-reactive protein (hs-CRP) were measured in all participants. After a follow-up period of 18 months for CHF patients, major cardiovascular events (MCE), including cardiac death and rehospitalization for heart failure, were recorded. Results: Plasma levels of S100A12 were significantly higher in CHF patients than in control subjects (P < 0.001) and positively correlated with hs-CRP (r = 0.316, P < 0.001). S100A12 levels were also higher in MCE patients than in MCE-free patients. The occurrence of MCE increased with advancing plasma S100A12 levels by stratification according to quartiles (Q4 vs Q1, P = 0.015). Cox proportional hazards regression analysis revealed that S100A12 was an independent risk factor for MCE in CHF patients (P = 0.009). Conclusions: S100A12 is a potential biomarker of CHF that may provide important information regarding the prediction of MCE in patients with CHF. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved,