Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

被引：84

作者：

Leclaire, J ^{[1
]}

Vial, L ^{[1
]}

Otto, S ^{[1
]}

Sanders, JKM ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 15期

关键词：

D O I：

10.1039/b500638d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dynamic combinatorial libraries have been prepared which feature two simultaneous covalent exchange reactions in aqueous solution at neutral pH. This allows for diversity, not only of the subunits that are linked, but also of the linkage itself.

引用

页码：1959 / 1961

页数：3

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