Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts

被引：10

作者：

Bongarzone, Salvatore ^{[1
,5
]}

Tran, Hoang Ngoc Ai ^{[2
]}

Cavalli, Andrea ^{[3
,6
]}

Roberti, Marinella ^{[6
]}

Rosini, Michela ^{[6
]}

Carloni, Paolo ^{[4
]}

Legname, Giuseppe ^{[1
,2
]}

Bolognesi, Maria Laura ^{[6
]}

机构：

[1] IIT, SISSA Unit, I-34014 Trieste, Italy

[2] SISSA, Lab Prion Biol, Neurobiol Sector, I-34136 Trieste, Italy

[3] IIT, Dept Drug Discovery & Dev, I-16163 Genoa, Italy

[4] Rhein Westfal TH Aachen, German Res Sch, Simulat Sci GmbH, Forschungszentrum Julich GmbH, Aachen, Germany

[5] SISSA, Stat & Biol Phys Sector, I-34136 Trieste, Italy

[6] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

来源：

CHEMMEDCHEM | 2011年 / 6卷 / 04期

关键词：

antioxidants; drug design; fibrillation inhibitors; medicinal chemistry; prion diseases; QUINOLINE DERIVATIVES; OXIDATIVE STRESS; DISCOVERY; ANTIPRION; LIGANDS; DESIGN; TARGET; DRUGS; GLYCOXIDATION; LIPOXIDATION;

D O I：

10.1002/cmdc.201100072

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

[No abstract available]

引用

页码：601 / 605

页数：5

共 41 条

[1]

Prions: Protein Aggregation and Infectious Diseases [J].

Aguzzi, Adriano ;

Calella, Anna Maria .

PHYSIOLOGICAL REVIEWS, 2009, 89 (04) :1105-1152

[2]

Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds [J].

Antonello, A ;

Hrelia, P ;

Leonardi, A ;

Marucci, G ;

Rosini, M ;

Tarozzi, A ;

Tumiatti, V ;

Melchiorre, C .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (01) :28-31

[3]

Multitarget-directed drug design strategy: A novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects [J].

Antonello, Alessandra ;

Tarozzi, Andrea ;

Morroni, Fabiana ;

Cavalli, Andrea ;

Rosini, Michela ;

Hrelia, Patrizia ;

Bolognesi, Maria Laura ;

Melchiorre, Carlo .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (23) :6642-6645

[4]

Increased lipid peroxidation in cerebrospinal fluid and plasma from patients with Creutzfeldt-Jakob disease [J].

Arlt, S ;

Kontush, A ;

Zerr, I ;

Buhmann, C ;

Jacobi, C ;

Schröter, A ;

Poser, S ;

Beisiegel, U .

NEUROBIOLOGY OF DISEASE, 2002, 10 (02) :150-156

[5]

Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration [J].

Bolognesi, Maria L. ;

Minarini, Anna ;

Tumiatti, Vincenzo ;

Melchiorre, Carlo .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2006, 6 (11) :1269-1274

[6]

Discovery of a Class of Diketopiperazines as Antiprion Compounds [J].

Bolognesi, Maria Laura ;

Tran, Hoang Ngoc Ai ;

Staderini, Matteo ;

Monaco, Alessandro ;

Lopez-Cobenas, Alberto ;

Bongarzone, Salvatore ;

Biarnes, Xevi ;

Lopez-Alvarado, Pilar ;

Cabezas, Nieves ;

Caramelli, Maria ;

Carloni, Paolo ;

Carlos Menendez, J. ;

Legname, Giuseppe .

CHEMMEDCHEM, 2010, 5 (08) :1324-1334

[7]

Toward a Rational Design of Multitarget-Directed Antioxidants: Merging Memoquin and Lipoic Acid Molecular Frameworks [J].

Bolognesi, Maria Laura ;

Cavalli, Andrea ;

Bergarmini, Christian ;

Fato, Romana ;

Lenaz, Giorgio ;

Rosini, Michela ;

Bartolini, Manuela ;

Andrisano, Vincenza ;

Melchiorre, Carlo .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (23) :7883-7886

[8]

The concept of privileged structures in rational drug design: focus on acridine and quinoline scaffolds in neurodegenerative and protozoan diseases [J].

Bongarzone, Salvatore ;

Bolognesi, Maria Laura .

EXPERT OPINION ON DRUG DISCOVERY, 2011, 6 (03) :251-268

[9]

Parallel Synthesis, Evaluation, and Preliminary Structure-Activity Relationship of 2,5-Diamino-1,4-benzoquinones as a Novel Class of Bivalent Anti-Prion Compound [J].

Bongarzone, Salvatore ;

Hoang Ngoc Ai Tran ;

Cavalli, Andrea ;

Roberti, Marinella ;

Carloni, Paolo ;

Legname, Giuseppe ;

Bolognesi, Maria Laura .

JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (22) :8197-8201

[10]

Prions and their partners in crime [J].

Caughey, Byron ;

Baron, Gerald S. .

NATURE, 2006, 443 (7113) :803-810

← 1 2 3 4 5 →