Multisubunit RNA polymerases IV and V: purveyors of non-coding RNA for plant gene silencing

被引：296

作者：

Haag, Jeremy R.

Pikaard, Craig S. ^{[1
]}

机构：

[1] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 08期

基金：

美国国家卫生研究院;

关键词：

DIRECTED DNA-METHYLATION; ARABIDOPSIS-THALIANA; POL-IV; ANTISENSE TRANSCRIPTS; PROCESSING CENTER; BINDING PROTEIN; SIRNA; PATHWAYS; REQUIRES; SUBUNIT;

D O I：

10.1038/nrm3152

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In all eukaryotes, nuclear DNA-dependent RNA polymerases I, II and III synthesize the myriad RNAs that are essential for life. Remarkably, plants have evolved two additional multisubunit RNA polymerases, RNA polymerases IV and V, which orchestrate non-coding RNA-mediated gene silencing processes affecting development, transposon taming, antiviral defence and allelic crosstalk. Biochemical details concerning the templates and products of RNA polymerases IV and V are lacking. However, their subunit compositions reveal that they evolved as specialized forms of RNA polymerase II, which provides the unique opportunity to study the functional diversification of a eukaryotic RNA polymerase family.

引用

收藏

页码：483 / 492

页数：10

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