Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases

被引:29
作者
Walker, DG
Terai, K
Matsuo, A
Beach, TG
McGeer, EG
McGeer, PL
机构
[1] Univ British Columbia, Dept Psychiat, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1Z3, Canada
[2] Univ British Columbia, Neurodegenerat Dis Ctr, Vancouver, BC V6T 1Z3, Canada
[3] Univ British Columbia, Dept Pathol, Vancouver, BC V6T 1Z3, Canada
基金
英国医学研究理事会;
关键词
dopaminergic; cell death; neurodegeneration; tyrosine kinase; neuron;
D O I
10.1016/S0006-8993(98)00132-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The use of neurotrophic growth factors as a means of preventing loss of the dopaminergic (DA) neurons in the substantia nigra (SN) is becoming an accepted treatment strategy for Parkinson's disease (PD). In earlier studies, we showed that there was a selective loss of basic fibroblast growth factor (bFGF) immunoreactivity in DA neurons of the SN in PD suggesting that a deficiency of bFGF might contribute to cell death. As a preliminary step to assessing the potential for using bFGF or its analogs as therapeutic agents, the expression of fibroblast growth factor receptor-1 (FGFR-1) in the SN of normal and PD cases was investigated immunohistochemically. FGFR-1 immunoreactivity could be detected in DA neurons of the SN in young and old neurologically normal cases with an apparent decline with age. FGFR-1 immunoreactivity was also detected in many of the residual SN neurons in most of the idiopathic PD cases. These results indicate that FGFR-1 immunoreactivity, and possibly FGF binding activity, is retained in DA neurons in PD. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:181 / 187
页数:7
相关论文
共 33 条
  • [31] COMPLEMENT C1 INHIBITOR IS PRODUCED BY BRAIN-TISSUE AND IS CLEAVED IN ALZHEIMER-DISEASE
    WALKER, DG
    YASUHARA, O
    PATSTON, PA
    MCGEER, EG
    MCGEER, PL
    [J]. BRAIN RESEARCH, 1995, 675 (1-2) : 75 - 82
  • [32] DIFFERENTIAL EXPRESSION OF 2 FIBROBLAST GROWTH FACTOR-RECEPTOR GENES IS ASSOCIATED WITH MALIGNANT PROGRESSION IN HUMAN ASTROCYTOMAS
    YAMAGUCHI, F
    SAYA, H
    BRUNER, JM
    MORRISON, RS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) : 484 - 488
  • [33] Growth factors rescue embryonic dopamine neurons from programmed cell death
    Zawada, WM
    Kirschman, DL
    Cohen, JJ
    Heidenreich, KA
    Freed, CR
    [J]. EXPERIMENTAL NEUROLOGY, 1996, 140 (01) : 60 - 67