Defensins: Antimicrobial peptides of innate immunity

被引：2284

作者：

Ganz, T ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Pathol, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1180

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The production of natural antibiotic peptides has emerged as an important mechanism of innate immunity in plants and animals. Defensins are diverse members of a large family of antimicrobial peptides, contributing to the antimicrobial action of granulocytes, mucosal host defence in the small intestine and epithelial host defence in the skin and elsewhere. This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins.

引用

页码：710 / 720

页数：11

共 163 条

[21] Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells
Diamond, G
Russell, JP
Bevins, CL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (10) : 5156 - 5160
[22] TRACHEAL ANTIMICROBIAL PEPTIDE, A CYSTEINE-RICH PEPTIDE FROM MAMMALIAN TRACHEAL MUCOSA - PEPTIDE ISOLATION AND CLONING OF A CDNA
DIAMOND, G
ZASLOFF, M
ECK, H
BRASSEUR, M
MALOY, WL
BEVINS, CL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) : 3952 - 3956
[23] Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells
Diamond, G
Kaiser, V
Rhodes, J
Russell, JP
Bevins, CL
[J]. INFECTION AND IMMUNITY, 2000, 68 (01) : 113 - 119
[24] Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids
Duits, LA
Rademaker, M
Ravensbergen, B
van Sterkenburg, MAJA
van Strijen, E
Hiemstra, PS
Nibbering, PH
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (02) : 522 - 525
[25] PURIFICATION AND ANTIMICROBIAL PROPERTIES OF 3 DEFENSINS FROM RAT NEUTROPHILS
EISENHAUER, PB
HARWIG, SSL
SZKLAREK, D
GANZ, T
SELSTED, ME
LEHRER, RI
[J]. INFECTION AND IMMUNITY, 1989, 57 (07) : 2021 - 2027
[26] MOUSE NEUTROPHILS LACK DEFENSINS
EISENHAUER, PB
LEHRER, RI
[J]. INFECTION AND IMMUNITY, 1992, 60 (08) : 3446 - 3447
[27] ISOLATION OF ANTIMICROBIAL PEPTIDES FROM AVIAN HETEROPHILS
EVANS, EW
BEACH, GG
WUNDERLICH, J
HARMON, BG
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1994, 56 (05) : 661 - 665
[28] Defensin-rich granules of human neutrophils: characterization of secretory properties
Faurschou, M
Sorensen, OE
Johnsen, AH
Askaa, J
Borregaard, N
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2002, 1591 (1-3): : 29 - 35
[29] DIFFERENCES IN THE INTERACTION OF HEPARIN WITH ARGININE AND LYSINE AND THE IMPORTANCE OF THESE BASIC-AMINO-ACIDS IN THE BINDING OF HEPARIN TO ACIDIC FIBROBLAST GROWTH-FACTOR
FROMM, JR
HILEMAN, RE
CALDWELL, EEO
WEILER, JM
LINHARDT, RJ
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 323 (02) : 279 - 287
[30] Expression of human α-defensin 5 (HD5) mRNA in nasal and bronchial epithelial cells
Frye, M
Bargon, J
Dauletbaev, N
Weber, A
Wagner, TOF
Gropp, R
[J]. JOURNAL OF CLINICAL PATHOLOGY, 2000, 53 (10) : 770 - 773

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